New York Giants running back Saquon Barkley sprained his ankle in Sunday’s 31-28 win over the Arizona Cardinals and is expected to be sidelined for three weeks, a source told ESPN’s Adam Schefter.

Barkley suffered the injury in the final seconds of the contest while being tackled during a run. He was unable to put weight on his right leg while being helped off the field. The 26-year-old’s postgame X-rays came back negative. An MRI on Monday showed Barkley only sustained an “ordinary” sprain, Schefter adds.

Barkley’s injury is a big blow to the Giants’ offense, which hasn’t looked great two games into the season. New York lost its season opener to the Dallas Cowboys 40-0 and didn’t score its first points until the third quarter versus Arizona in Week 2.

Despite the slow start Sunday, the Giants rallied from a 21-point deficit to beat the Cardinals, with Barkley being an integral part. The Pro Bowl tailback finished the game with 92 scrimmage yards and two total touchdowns.

Injuries have been an issue for Barkley throughout his career, as the Penn State product missed 20 games from 2019-21. He managed to stay healthy in 2022 and finished the campaign with 1,650 scrimmage yards to go along with 10 scores.

Barkley has racked up 6,224 total yards and 39 touchdowns in 62 appearances since the Giants selected him second overall in 2018.

New York visits the San Francisco 49ers on Thursday Night Football in Week 3. The Giants then face the Seattle Seahawks and Miami Dolphins in the following weeks.

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